General Information

  • ID:  hor005261
  • Uniprot ID:  P29205
  • Protein name:  Peptide YY-like (PYY)
  • Gene name:  pyy
  • Organism:  Amia calva (Bowfin)
  • Family:  NPY family
  • Source:  animal
  • Expression:  pancreas
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Amia (genus), Amiidae (family), Amiiformes (order), Holostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YPPKPENPGEDAPPEELARYYTALRHYINLITRQRY
  • Length:  36
  • Propeptide:  YPPKPENPGEDAPPEELARYYTALRHYINLITRQRY
  • Signal peptide:  NA
  • Modification:  T36 Tyrosine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P29205-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P29205-F1.pdbhor005261_AF2.pdbhor005261_ESM.pdb

Physical Information

Mass: 495729 Formula: C197H296N54O57
Absent amino acids: CFMSVW Common amino acids: P
pI: 7.52 Basic residues: 6
Polar residues: 10 Hydrophobic residues: 8
Hydrophobicity: -125.56 Boman Index: -9954
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 62.5
Instability Index: 7340.83 Extinction Coefficient cystines: 7450
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  2067973
  • Title:  Neuropeptide Y-related peptides from the pancreas of a teleostean (eel), holostean (bowfin) and elasmobranch (skate) fish.